What is 4-AcO-DMT?
4-AcO Dose Ranges for Intranasal Ingestion
Similarities between 4-AcO-DMT And Mushrooms
Safety and toxicity
Taking into account the pharmacological similarities, we can assume that 4-AcO-DMT is just as safe and non-addictive as psilocybin/psilocin. Although clinical research is lacking—especially into its long-term effects and toxic overdose (if any) anecdotal reports support its presumed safety. However, a number of 4-AcO-DMT trip reports report that very high doses can cause blackouts, vomiting, heart problems, hypertension, and seizures. No fatalities have been reported—at least in the absence of other drugs.
4-AcO-DMT Side Effects?
According to my survey data, psilacetin side effects resemble those of psilocybin. For instance, nausea on the come-up is common, especially if users had some food in their stomachs. Like with mushrooms, it’s best to fast for a few hours before consumption in order to avoid stomach upset. Interestingly, many report the nausea subsided and a body euphoria with pain relieving effects took over, especially after the peak. In fact, the nausea seems to be less intense than with mushrooms for some folks, and many have speculated the reason is that there’s no mushroom material to digest, like chitin, the protein that makes up the cell walls of fungi.