2C-B Drug is a novel psychoactive substance that was invented by biochemist and psychopharmacologist Alexander “Sasha” Shulgin in 1974. Shulgin is known as the “Godfather of Ecstasy” and legally synthesized over 200 psychedelic compounds in a musty lab on his property in the Bay Area known as “the Farm.” Serving as his own guinea pig, he tested all these compounds on himself, and if he found them to be safe and possibly useful, extended the invitation to his wife, Ann Shulgin, as well as to their “research group.” These chemical tales are joyously recounted in the couple’s co-authored books, PiHKAL (Phenethylamines I Have Known and Loved) and TiHKAL (Tryptamines I Have Known and Loved). (Tryptamines include the classic psychedelics like LSD or psilocybin, while phenethylamines include 2C-B.)
Effects of 2c-B Drugs
2C-B is usually swallowed as a capsule, tablet, or powder, or sometimes dissolved in a liquid and then swallowed. Tablets have been reported to be pink, purple, red, off-white, off-white with brown specks, or beige, sometimes with a bullhead logo stamped on the pills. Capsules may contain pink, white, or off-white powder. Snorting the drug leads to a burning sensation and is very painful. Beginning a high with pain from snorting may lead to an unpleasant experience overall. Users will start to feel the effects in about 30 minutes of consuming the drug. The first effects are reportedly feelings of anticipation, warmth, anxiety, and tingling. Sexual and physical arousal may occur and may remain throughout the high. Signs of this include erection-raised hairs, chills, tremors, muscle spasms, and dilated pupils. Feelings of euphoria, similar to the effects of MDMA, will likely occur. A light dose is considered to be between 5 and 15mg, while anything above 25mg is considered strong.
Vital Signs/Physiological Effects
Systolic blood pressure (SBP), diastolic blood pressure (DBP), and heart rate (HR) were measured with an automatic Omron® monitor at baseline and 1, 2, 3, 4, and 6 h after self-administration.
Subjective Effects 2c-B Drug
Subjective effects were recorded at baseline and 2 h after administration, at 6 h subjects were asked to report the maximum effects along 6 h (0–6 h). The Hallucinogenic Rating Scale (HRS) was completed only at 6 h post-administration.
Subjective effects of 2C-B were measured using a set of the visual analog scale (VAS), the Addiction Research Center Inventory (ARCI), the Evaluation of the Subjective Effects of Substances with Abuse Potential (VESPA-SSE) questionnaires, and the HRS.
2c-B Drug has been described as a cross between MDMA and LSD.
Users may experience hallucinations that are usually mild visual effects like facial distortions, moving surfaces, enhanced or shifting colors, or feeling like they can see sounds. Higher doses may lead to more intense hallucinations that are unpleasant or frightening. Claustrophobia and muscle clenching have been reported. Some users experience nausea, vomiting, gas, or diarrhea, while others may have a surge of negative emotions like fear, anger, or grief. Overall, users should experience increased sociability, but it may be difficult or confusing to have a conversation with another person. It is common to have introspective thoughts while under the influence of 2C-B and to experience increased empathy and a softening of the ego.